Autophagy participates in innate immune defense in lamprey.
Identifieur interne : 000653 ( Main/Exploration ); précédent : 000652; suivant : 000654Autophagy participates in innate immune defense in lamprey.
Auteurs : Lingjie Luo [République populaire de Chine] ; Juan Lu [République populaire de Chine] ; Qin Wang [République populaire de Chine] ; Shangwu Chen [République populaire de Chine] ; Anlong Xu [République populaire de Chine] ; Shaochun Yuan [République populaire de Chine]Source :
- Fish & shellfish immunology [ 1095-9947 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Autophagie (immunologie), Bécline-1 (génétique), Cellules HEK293 (MeSH), Danio zébré (MeSH), Escherichia coli (MeSH), Humains (MeSH), Immunité innée (MeSH), Lamproies (immunologie), Lancelets (MeSH), Leucocytes (effets des médicaments et des substances chimiques), Leucocytes (immunologie), Lipopolysaccharides (pharmacologie), Poly I-C (pharmacologie), Saccharomyces cerevisiae (MeSH), Staphylococcus aureus (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Leucocytes.
- génétique : Bécline-1.
- immunologie : Autophagie, Lamproies, Leucocytes.
- pharmacologie : Lipopolysaccharides, Poly I-C.
- Animaux, Cellules HEK293, Danio zébré, Escherichia coli, Humains, Immunité innée, Lancelets, Saccharomyces cerevisiae, Staphylococcus aureus.
English descriptors
- KwdEn :
- Animals (MeSH), Autophagy (immunology), Beclin-1 (genetics), Escherichia coli (MeSH), HEK293 Cells (MeSH), Humans (MeSH), Immunity, Innate (MeSH), Lampreys (immunology), Lancelets (MeSH), Leukocytes (drug effects), Leukocytes (immunology), Lipopolysaccharides (pharmacology), Poly I-C (pharmacology), Saccharomyces cerevisiae (MeSH), Staphylococcus aureus (MeSH), Zebrafish (MeSH).
- MESH :
- chemical , genetics : Beclin-1.
- drug effects : Leukocytes.
- immunology : Autophagy, Lampreys, Leukocytes.
- chemical , pharmacology : Lipopolysaccharides, Poly I-C.
- Animals, Escherichia coli, HEK293 Cells, Humans, Immunity, Innate, Lancelets, Saccharomyces cerevisiae, Staphylococcus aureus, Zebrafish.
Abstract
Autophagy is a homeostatic process which degrades cytoplasmic constituents to maintain the balance of organs when they were challenged with nutrient stress. It also participates in cancer, neurodegenerative disorders, aging and innate immune defense. In order to reveal how autophagy participates in innate immune response when invertebrates evolved into vertebrates. Firstly, we performed a systematic analysis of Atg genes and found that they are highly conserved among lancelet, lamprey and zebrafish. Then, we observed autophagosomes upon starvation by TEM in lancelet, lamprey and zebrafish and found that the morphology of autophagosome is similar to that was observed in yeast and mammals. In addition, rapamycin can induce autophagy in lamprey leukocytes and the deficiency of human Beclin1 protein can be rescued by lancelet and lamprey Beclin1 proteins. When lamprey leukocytes were treated with polyI:C and LPS, autophagy was induced. Moreover, when lamprey leukocytes were challenged with live E. coli, phagocytosis along with autophagy was triggered to degrade pathogenic bacteria. In all, our study here indicated that autophagy is highly conserved during evolution and plays a key role in innate defense when invertebrates evolved into vertebrates.
DOI: 10.1016/j.fsi.2018.09.016
PubMed: 30195918
Affiliations:
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Electronic address: lssxal@mail.sysu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China; School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029</wicri:regionArea><wicri:noRegion>100029</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Shaochun" sort="Yuan, Shaochun" uniqKey="Yuan S" first="Shaochun" last="Yuan">Shaochun Yuan</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, People's Republic of China. Electronic address: yuanshch@mail.sysu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao</wicri:regionArea><wicri:noRegion>Qingdao</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30195918</idno><idno type="pmid">30195918</idno><idno type="doi">10.1016/j.fsi.2018.09.016</idno><idno type="wicri:Area/Main/Corpus">000459</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000459</idno><idno type="wicri:Area/Main/Curation">000459</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000459</idno><idno type="wicri:Area/Main/Exploration">000459</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Autophagy participates in innate immune defense in lamprey.</title><author><name sortKey="Luo, Lingjie" sort="Luo, Lingjie" uniqKey="Luo L" first="Lingjie" last="Luo">Lingjie Luo</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Lu, Juan" sort="Lu, Juan" uniqKey="Lu J" first="Juan" last="Lu">Juan Lu</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Chen, Shangwu" sort="Chen, Shangwu" uniqKey="Chen S" first="Shangwu" last="Chen">Shangwu Chen</name><affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Xu, Anlong" sort="Xu, Anlong" uniqKey="Xu A" first="Anlong" last="Xu">Anlong Xu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China; School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China. Electronic address: lssxal@mail.sysu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China; School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029</wicri:regionArea><wicri:noRegion>100029</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Shaochun" sort="Yuan, Shaochun" uniqKey="Yuan S" first="Shaochun" last="Yuan">Shaochun Yuan</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, People's Republic of China. Electronic address: yuanshch@mail.sysu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao</wicri:regionArea><wicri:noRegion>Qingdao</wicri:noRegion></affiliation></author></analytic><series><title level="j">Fish & shellfish immunology</title><idno type="eISSN">1095-9947</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Autophagy (immunology)</term><term>Beclin-1 (genetics)</term><term>Escherichia coli (MeSH)</term><term>HEK293 Cells (MeSH)</term><term>Humans (MeSH)</term><term>Immunity, Innate (MeSH)</term><term>Lampreys (immunology)</term><term>Lancelets (MeSH)</term><term>Leukocytes (drug effects)</term><term>Leukocytes (immunology)</term><term>Lipopolysaccharides (pharmacology)</term><term>Poly I-C (pharmacology)</term><term>Saccharomyces cerevisiae (MeSH)</term><term>Staphylococcus aureus (MeSH)</term><term>Zebrafish (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Autophagie (immunologie)</term><term>Bécline-1 (génétique)</term><term>Cellules HEK293 (MeSH)</term><term>Danio zébré (MeSH)</term><term>Escherichia coli (MeSH)</term><term>Humains (MeSH)</term><term>Immunité innée (MeSH)</term><term>Lamproies (immunologie)</term><term>Lancelets (MeSH)</term><term>Leucocytes (effets des médicaments et des substances chimiques)</term><term>Leucocytes (immunologie)</term><term>Lipopolysaccharides (pharmacologie)</term><term>Poly I-C (pharmacologie)</term><term>Saccharomyces cerevisiae (MeSH)</term><term>Staphylococcus aureus (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Beclin-1</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Leukocytes</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Leucocytes</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Bécline-1</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Autophagie</term><term>Lamproies</term><term>Leucocytes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Autophagy</term><term>Lampreys</term><term>Leukocytes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Lipopolysaccharides</term><term>Poly I-C</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Lipopolysaccharides</term><term>Poly I-C</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Escherichia coli</term><term>HEK293 Cells</term><term>Humans</term><term>Immunity, Innate</term><term>Lancelets</term><term>Saccharomyces cerevisiae</term><term>Staphylococcus aureus</term><term>Zebrafish</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules HEK293</term><term>Danio zébré</term><term>Escherichia coli</term><term>Humains</term><term>Immunité innée</term><term>Lancelets</term><term>Saccharomyces cerevisiae</term><term>Staphylococcus aureus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Autophagy is a homeostatic process which degrades cytoplasmic constituents to maintain the balance of organs when they were challenged with nutrient stress. It also participates in cancer, neurodegenerative disorders, aging and innate immune defense. In order to reveal how autophagy participates in innate immune response when invertebrates evolved into vertebrates. Firstly, we performed a systematic analysis of Atg genes and found that they are highly conserved among lancelet, lamprey and zebrafish. Then, we observed autophagosomes upon starvation by TEM in lancelet, lamprey and zebrafish and found that the morphology of autophagosome is similar to that was observed in yeast and mammals. In addition, rapamycin can induce autophagy in lamprey leukocytes and the deficiency of human Beclin1 protein can be rescued by lancelet and lamprey Beclin1 proteins. When lamprey leukocytes were treated with polyI:C and LPS, autophagy was induced. Moreover, when lamprey leukocytes were challenged with live E. coli, phagocytosis along with autophagy was triggered to degrade pathogenic bacteria. In all, our study here indicated that autophagy is highly conserved during evolution and plays a key role in innate defense when invertebrates evolved into vertebrates.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30195918</PMID><DateCompleted><Year>2019</Year><Month>02</Month><Day>14</Day></DateCompleted><DateRevised><Year>2019</Year><Month>02</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9947</ISSN><JournalIssue CitedMedium="Internet"><Volume>83</Volume><PubDate><Year>2018</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Fish & shellfish immunology</Title><ISOAbbreviation>Fish Shellfish Immunol</ISOAbbreviation></Journal><ArticleTitle>Autophagy participates in innate immune defense in lamprey.</ArticleTitle><Pagination><MedlinePgn>416-424</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1050-4648(18)30552-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.fsi.2018.09.016</ELocationID><Abstract><AbstractText>Autophagy is a homeostatic process which degrades cytoplasmic constituents to maintain the balance of organs when they were challenged with nutrient stress. It also participates in cancer, neurodegenerative disorders, aging and innate immune defense. In order to reveal how autophagy participates in innate immune response when invertebrates evolved into vertebrates. Firstly, we performed a systematic analysis of Atg genes and found that they are highly conserved among lancelet, lamprey and zebrafish. Then, we observed autophagosomes upon starvation by TEM in lancelet, lamprey and zebrafish and found that the morphology of autophagosome is similar to that was observed in yeast and mammals. In addition, rapamycin can induce autophagy in lamprey leukocytes and the deficiency of human Beclin1 protein can be rescued by lancelet and lamprey Beclin1 proteins. When lamprey leukocytes were treated with polyI:C and LPS, autophagy was induced. Moreover, when lamprey leukocytes were challenged with live E. coli, phagocytosis along with autophagy was triggered to degrade pathogenic bacteria. In all, our study here indicated that autophagy is highly conserved during evolution and plays a key role in innate defense when invertebrates evolved into vertebrates.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Lingjie</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Juan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Qin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Shangwu</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Anlong</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China; School of Life Science, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China. Electronic address: lssxal@mail.sysu.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Shaochun</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, People's Republic of China. Electronic address: yuanshch@mail.sysu.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>09</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Fish Shellfish Immunol</MedlineTA><NlmUniqueID>9505220</NlmUniqueID><ISSNLinking>1050-4648</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000071186">Beclin-1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>O84C90HH2L</RegistryNumber><NameOfSubstance UI="D011070">Poly I-C</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="N">Autophagy</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000071186" MajorTopicYN="N">Beclin-1</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057809" MajorTopicYN="N">HEK293 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="Y">Immunity, Innate</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007798" MajorTopicYN="N">Lampreys</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064175" MajorTopicYN="N">Lancelets</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007962" MajorTopicYN="N">Leukocytes</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011070" MajorTopicYN="N">Poly I-C</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015027" MajorTopicYN="N">Zebrafish</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Atg genes</Keyword><Keyword MajorTopicYN="N">Autophagosome</Keyword><Keyword MajorTopicYN="N">Autophagy</Keyword><Keyword MajorTopicYN="N">Beclin1</Keyword><Keyword MajorTopicYN="N">Lamprey</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>07</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>08</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>09</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>2</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30195918</ArticleId><ArticleId IdType="pii">S1050-4648(18)30552-7</ArticleId><ArticleId IdType="doi">10.1016/j.fsi.2018.09.016</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Luo, Lingjie" sort="Luo, Lingjie" uniqKey="Luo L" first="Lingjie" last="Luo">Lingjie Luo</name></region><name sortKey="Chen, Shangwu" sort="Chen, Shangwu" uniqKey="Chen S" first="Shangwu" last="Chen">Shangwu Chen</name><name sortKey="Lu, Juan" sort="Lu, Juan" uniqKey="Lu J" first="Juan" last="Lu">Juan Lu</name><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name><name sortKey="Xu, Anlong" sort="Xu, Anlong" uniqKey="Xu A" first="Anlong" last="Xu">Anlong Xu</name><name sortKey="Yuan, Shaochun" sort="Yuan, Shaochun" uniqKey="Yuan S" first="Shaochun" last="Yuan">Shaochun Yuan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Autophagy participates in innate immune defense in lamprey.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30195918" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |